Currently, most anti-neoplastic drugs exhibit cytotoxic properties, while other highly potent drugs, such as hormonal agents, can exert significant biological effects even in trace amounts.

Additionally, certain highly allergenic drugs contain components that, upon entering the human body, stimulate the immune system to produce specific antibodies, thereby sensitizing the individual to the allergen.

Therefore, if operators are exposed to such high-risk environments during production, it can lead to irreversible damage to human cells. Moreover, the inhalation of dust particles also poses a risk of cross-contamination between products.

The principle of high containment is to isolate hazardous drugs from personnel and the environment through containment systems.

Currently, the industry typically employs two methods: one is to protect the personnel by having operators wear PPE (Personal Protective Equipment), and the other is to contain the hazardous dust within the equipment itself.

At Canaan, we focus on the latter approach, ensuring that hazardous dust is fully enclosed within the equipment.

Implementing high containment in equipment is the most cost-effective and safest measure.

With in-depth research and  extensive practical experience  in high-containment technologies, we have developed a  high-containment product platform  based on containment characteristics.

Canaan’s high-containment technology covers the entire operational process, ensuring:  

– Containment During Production

– Containment During Cleaning And Maintenance

– Containment During Abnormal Failures

This comprehensive approach guarantees the safety of operators and the protection of the environment.

All Canaan high-containment equipment implements:

• Multi-state leakage inspection
• Pressure-holding leakage rate testing before operation
• Leakage testing protocols strictly adhere to ISO 10648-2 standards for containment classification and verification methodologies

According to the solid dosage pharmaceutical process, Canaan has achieved high-containment design for various process equipment, ranging from raw material crushing, screening, and weighing to granulation, mixing, tabletting, coating, capsule filling, and packaging.

Moreover, Canaan not only provides equipment but, more importantly, offers a complete set of high-containment solutions for R&D, pilot-scale production, and commercial large-scale production.

Over the past few years, we have collaborated with our clients to successfully complete several high-containment production lines, including  R&D high-containment wet granulation lines, pilot-scale dry granulation equipment  and wet granulation line,  large-scale wet granulation lines , and  direct compression process lines. These projects have resulted in the successful implementation of multiple OEB5-rated production lines, which have passed rigorous testing by third-party authoritative inspection agencies. 

Our equipment is designed to protect the safety of operators  in the pharmaceutical industry,  minimize cross-contamination between drugs , and  control the environmental hazards  associated with production processes. Canaan is committed to providing  high-quality equipment  and  comprehensive solutions  that empower the industry’s development.

Canaan has the ability to integrate full life cycle services, and can provide integrated solutions from the design phase, equipment selection, installation and commissioning, qualification and validation, operation and maintenance services, covering the entire pharmaceutical production chain.

Canaan can provide customers with the equipment needed for pharmaceutical production, especially the production of API and solid preparations. All equipment from production to packaging is independently produced, which makes Canaan equipment have great advantages in continuous production, intelligent manufacturing, and digital twins. It can be customized for customers’ entire lines and greatly save operation and maintenance costs.

In terms of engineering design, Canaan Technology has a team of senior EPC engineers. They have successful case experiences in Asia Pacific, Europe, the Middle East, Africa, Latin America and the Russian-speaking area, and have a deep understanding of the GMP specifications and regulations in different places. Canaan engineers are proficient in BIM design and can design the best solution for customers.