The production line consists of a Hot-melt Extrusion, a feeder, a slurry feeder, and a pulverizer. The active ingredient (API) and excipients of the drug can be transported to the Hot-melt Extrusion through the slurry feeder and the feeder. During the hot melt extrusion process, the input material is added to the barrel with stage-by-stage temperature control. The barrel is provided with a threaded element, which performs different unit operations from the feeding part to the die head in sequence. The material moves forward under the conveying action of the threaded element and melts or softens in the melting section. The melt is evenly mixed under the action of the mixing element, and finally extruded from the die at a certain pressure, speed and shape. The pulverizer completes the continuous cooling, solidification and pulverization of the hot melt extrudate.
1. Continuous process, high efficiency
2. Fewer process steps
3. High repeat-ability
4. Solvent-free
5. Online monitoring of process parameters
6. Low fixed investment
7. Meet GMP/cGMP/FDA/CE requirements
| Model | JR8 | JR16 | JR18 | JR20 | JR25 | JR34 | |||||
| Aspect Ratio | 20 | 20 | 30 | 20 | 30 | 40 | 27 | 20 | 30 | 40 | 40 |
| Screw Diameter | 8 | 16 | 16 | 18 | 18 | 18 | 20 | 25 | 25 | 25 | 33.4 |
| Maximum Speed | 300 | 600 | 600 | 600 | 600 | 600 | 600 | 1000 | 1000 | 1000 | 739 |
| Torque | 6 | 15 | 15 | 32 | 32 | 32 | 35.8 | 100 | 100 | 100 | 140 |
| Maximum Power | 0.5 | 2 | 2 | 5 | 5 | 5 | 6.5 | 25 | 25 | 25 | 37 |
| Productivity | 0.005-0.05 | 0.02-2 | 0.02-2 | 0.05-5 | 0.05-5 | 0.05-5 | 0.5-10 | 5-20 | 5-20 | 5-20 | 100-200 |
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