---
title: "Budesonide Enteric Capsules (Part II): Micro-Pellet Filling & Hard Capsule Sealing Explained"
date: 2025-12-26T05:17:58Z
modified: 2026-01-06T02:02:14Z
permalink: "https://www.chinacanaan.com/blog/budesonide-enteric-capsules-case-sharing%ef%bd%9cmicro-pellet-filling-hard-capsule-sealing-explained/"
type: post
status: publish
excerpt: ""
wpid: 5049
categories:
  - Blog
  - Capsule Filling
  - News
featured_image: "https://www.chinacanaan.com/wp-content/uploads/2025/12/5b23e109-b989-413e-bc3e-2e816793874a.png"
timestamp: 2026-01-06T02:02:14Z
tags:
  - Blog
  - Capsule Filling
  - News
---

In the production of budesonide enteric capsules, **precise micro-pellet filling and reliable capsule sealing** are critical steps to ensure dose uniformity and the integrity of the enteric barrier. These two processes directly determine whether the final product can safely reach the intestine and release the drug accurately at the target site.

![](https://www.chinacanaan.com/wp-content/uploads/2025/12/5b23e109-b989-413e-bc3e-2e816793874a-1024x576.png)

![](https://www.chinacanaan.com/wp-content/uploads/2025/12/9a85fc9f-cfbb-4e32-a83f-332ea28c5d3b-1024x639.png)

### **Micro-Pellet Filling: Accurate Dosing, Gentle Filling**

Accurately filling micro-pellets—coated with three functional sustained-release layers—into hard capsules is the core step in controlling the final dosage. The CAP Series Hard Capsule Filling Machine provides an efficient and highly precise solution for this application.

Its optional dedicated micro-pellet filling station offers the following advantages:

**Flexible Changeover:

Micro-pellet and powder filling stations can be quickly exchanged without repeated disassembly of the drive system, supporting efficient multi-product manufacturing.



**Gentle Handling:

A pusher-plate filling mechanism with a short stroke and low applied force is used to minimize abrasion of the pellet coating. Wear of the sustained-release layer is kept **below 0.2%**, effectively preserving the drug release profile.



**High Dosing Accuracy:

Equipped with adjustable dosing molds offering up to a 60% adjustment range, the system flexibly accommodates different fill weights, with fill weight deviation consistently controlled **within ±2%**.



**Smooth Material Flow:

The dosing plate can be optionally fitted with a vibration device to effectively eliminate pellet bridging and electrostatic adhesion, ensuring a continuous and stable filling process.













### **Capsule Sealing: Securely Sealed, Refined Appearance**

After filling, the capsules must be sealed. Beyond improving appearance, sealing is essential to ensure tight capsule closure during subsequent enteric coating, transportation, and storage—preventing moisture ingress or content leakage.

Canaan **NSF800 Capsule Sealing Machine** provides reliable performance for this process:

- **Uniform Adhesive Application:**
    Secondary adhesive application technology ensures more even glue distribution, resulting in a firm, clean, and aesthetically pleasing sealing line.
- **Precise Temperature Control:**
    The glue tank features a thermally insulated design combined with high-sensitivity temperature sensors, enabling accurate real-time control of adhesive temperature for safe and stable operation.
- **Easy Cleaning:**
    The glue tank is connected to the main unit via a pneumatic clutch, allowing quick disassembly for thorough cleaning and full compliance with GMP requirements.
- **Damage-Free Conveying:**
    A precision chain-plate capsule conveying system, integrated with a fully containment low-temperature drying system, ensures orderly capsule alignment during conveying and drying, prevents mechanical damage, and maintains drug stability.

![](https://www.chinacanaan.com/wp-content/uploads/2025/12/a1f76567-47b8-496f-ad1c-9d39a420e144.jpg)









The combination of precise micro-pellet filling and reliable capsule sealing provides dual protection for both **content uniformity** and **capsule shell integrity** in budesonide enteric capsules. Through highly automated and refined equipment solutions, a solid foundation is established for the large-scale, high-quality production of this advanced dosage form.

## **From Lab Trials to Mass Production: Canaan Delivers Proven Process Pathways**

Canaan Solid Dosage Form R&D Center is equipped with a complete testing platform covering **laboratory-scale to pilot-scale** studies, offering customers:

✅ Development and parameter optimization of **enteric coating processes for hard capsules**

✅ Integrated process testing to ensure seamless interfacing between Fluid-bed micro-pellet drug layering** and **capsule filling operations



Process solutions based on real production cases, helping shorten customer project timelines.