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The fluidized bed granulation method is to keep the drug powder suspended in a fluidized state under the action of bottom-up airflow, and the binder liquid is sprayed from the upper or lower part into the fluidization chamber to make the powder agglomerate into granules.
The fluidized bed granulation method refers to the method in which the drug powder remains suspended and fluidized under the action of the bottom-up airflow, and the binder liquid is sprayed from the upper or lower part into the fluidization chamber to make the powder agglomerate into particles, referred to as flow Chemical granulation or boiling granulation. Fluidized bed granulation is also a kind of wet granulation.
Its structure is actually very related to its working method. It is mainly composed of the following parts: nozzles, catching bags, containers, sieve plates, air inlets and outlets, material inlets and outlets.
The working principle of fluidized bed granulation is mainly that the purified air enters the container through the sieve plate after heating, and then the hot material is added so that it can be in a fluid state. At this time, the binder must be sprayed in the form of a mist to make the material powder agglomerate into particle cores, which can gradually become larger to form full particles, and then need to be dried simultaneously. At this time, the liquid between the powders The bridge will be converted into a solid bridge, so that a porous, soft particle with a larger surface area can be obtained
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