--- title: What Is the Manufacturing Process of OSD? date: 2025-12-01T09:28:08Z modified: 2025-12-01T09:28:08Z permalink: "https://www.chinacanaan.com/blog/pharmaceutical-equipment-blog/osd-manufacturing-process-steps-equipment-guide/" type: post status: publish excerpt: "" wpid: 4770 categories: - Pharmaceutical Equipment featured_image: "https://www.chinacanaan.com/wp-content/uploads/2025/11/image-1764257553945-714.webp" featured_image_alt: A pharmaceutical technician inspecting white tablets, representing the OSD Manufacturing Process timestamp: 2025-12-01T09:28:08Z tags: - Pharmaceutical Equipment --- The [OSD manufacturing process](https://www.chinacanaan.com/wp-content/uploads/wp-mfa-exports/post/digital-empowerment-integrated-solution-for-solid-dosage-intelligent-factory.md), short for Oral Solid Dosage, refers to the complete production workflow that transforms raw pharmaceutical ingredients into finished products, such as tablets or capsules. This process includes several highly controlled stages: pre-treatment, granulation, blending, tablet compression, coating, and packaging. Each step is vital to ensure product safety, consistency, and therapeutic effectiveness. For manufacturers, understanding this process is key to maintaining quality standards, meeting regulatory requirements, and achieving production efficiency. In this article, we’ll walk you through the entire oral solid dosage manufacturing process step by step, explain its significance, and showcase how Canaan’s automation and smart technologies make this process more efficient and GMP-compliant. ![](https://www.chinacanaan.com/wp-content/uploads/2025/11/image-1764257553945-714-1-1024x683.webp) ## Raw Material Pre-treatment: Laying the Foundation Every successful OSD production starts with precise raw material pre-treatment. This step involves weighing, sieving, and de-lumping of both active pharmaceutical ingredients (APIs) and excipients. Canaan’s automated [dust-free feeding equipment](https://www.chinacanaan.com/products/dust-free-feeding-equipment/) is designed to reduce manual handling while improving material accuracy and cleanliness. Key benefits: - Ensures accurate ingredient dosing - Removes contaminants and oversized particles - Streamlines integration with downstream processes [ ![Dust-Free Feeding Equipment](https://www.chinacanaan.com/wp-content/uploads/2025/03/%E6%8A%95%E6%96%99%E7%AB%991.png) Dust-Free Feeding Equipment Automated system essential for pre-treatment, ensuring accurate ingredient dosing and cleanliness by minimizing manual handling and airborne particles. View Product ](https://www.chinacanaan.com/products/dust-free-feeding-equipment/)## Granulation: Enhancing Flow and Compressibility Granulation improves the physical characteristics of powders, making them easier to compress into uniform tablets. Two main types are used in oral solid dosage manufacturing: - **Wet granulation:** Involves mixing powders with a liquid binder. Canaan’s [X Series Wet Granulation Line](https://www.chinacanaan.com/products/x-series-wet-granulation-line/) integrates mixing, drying, and coating, ideal for complex formulations. - **Dry granulation:** Used when APIs are sensitive to heat or moisture. Canaan’s [Roller Compactors](https://www.chinacanaan.com/products/lgx-series-roller-compactor/) create granules through compaction, avoiding the need for liquids. This stage improves flowability, reduces dust, and ensures content uniformity. [ ![LGX Series Roller Compactor](https://www.chinacanaan.com/wp-content/uploads/2024/06/d975d66c109bd8da160c.png) LGX Series Roller Compactor The solvent-free dry granulation solution of choice for heat-sensitive APIs, producing granules with improved flowability and density without the use of liquids or heating. View Product ](https://www.chinacanaan.com/products/lgx-series-roller-compactor/)## Blending: Achieving Uniformity After granulation, ingredients go through blending, where APIs and excipients are uniformly mixed to ensure each tablet or capsule delivers the correct dosage. Canaan’s [bin blenders](https://www.chinacanaan.com/products/hgd-series-bin-blender/) and lifter systems guarantee high-efficiency powder mixing with minimal segregation, even for large batch volumes. Blending ensures: - Uniform API distribution - Reduced dosage variation - Scalable output for commercial production [ ![HTD Series Post Bin Blender](https://www.chinacanaan.com/wp-content/uploads/2024/06/990cf6c570d907177db1-2.png) HTD Series Post Bin Blender Guarantees the uniform blending of APIs and excipients in large batches, using lifter systems and bins to prevent segregation and ensure dosage accuracy. View Blender ](https://www.chinacanaan.com/products/htd-series-post-bin-blender/)## Tablet Compression: Forming the Final Product Next comes tablet compression, where granulated material is pressed into tablets. This stage requires precision and consistency. Canaan’s servo-controlled [tablet press machines](https://www.chinacanaan.com/products/t700-double-discharge-high-speed-tablet-press/) are designed for high-speed, GMP-compliant production, featuring turret changeover, real-time rejection, and process monitoring capabilities. Tablet press machines from Canaan provide: - High output with minimal waste - Enhanced safety features - Full automation for ease of operation [ ![T700 Double Discharge High Speed Tablet Press](https://www.chinacanaan.com/wp-content/uploads/2024/08/3cf0f3208099b598ce27-1.png) T700 High Speed Tablet Press Servo-controlled compression machine designed for high output, precise weight control, and GMP compliance, featuring real-time rejection and process monitoring. View Press ](https://www.chinacanaan.com/products/t700-double-discharge-high-speed-tablet-press/)## Film Coating: Protection and Functionality Film coating adds a thin protective layer to tablets, improving taste, appearance, and stability. Coatings can also be functional, such as enteric or controlled-release coatings. Canaan’s [BGX Series Coaters](https://www.chinacanaan.com/products/bgx-series-coater/) use closed-system technology with automated cleaning (CIP), precise spray guns, and low material loss. This step improves: - Tablet durability and shelf life - Patient compliance (taste masking) - Drug release performance [ ![BGX Series Coater](https://www.chinacanaan.com/wp-content/uploads/2024/06/d199139dd4fc85cbe0f5.png) BGX Series Coater High-efficiency film coating system featuring closed-loop technology, precise spray guns, and automated CIP to ensure tablet durability and optimal drug release. View Coater ](https://www.chinacanaan.com/products/bgx-series-coater/)## Blister Packaging: Final Delivery to Market In the final stage, tablets or capsules are packaged in blisters or filled into bottles. Canaan’s advanced packaging lines offer full automation, from bottle unscrambling to labeling and palletizing. These systems utilise intelligent counting to ensure accuracy and support high-speed blister packaging for maximum productivity. Packaging lines ensure: - GMP-compliant sealing and labeling - Tamper-proof and hygienic delivery - Flexible formats for tablets, capsules, and granules ## Why Choose Canaan’s OSD Manufacturing Solutions? Canaan offers an end-to-end pharmaceutical workflow for oral solid dosage forms—covering everything from material handling to final packaging. Their intelligent equipment supports continuous processing, process scale-up, and seamless integration between stages. Canaan is trusted for providing: - Turnkey production lines - Automation and digitization at every stage - Global support and after-sales service Explore our complete [Oral Solid Dosage Equipment Collection](https://www.chinacanaan.com/wp-content/uploads/wp-mfa-exports/page/solution.md) to find the right solutions for your facility. ## Conclusion If you’re aiming to modernize your OSD manufacturing process, choosing the right equipment partner matters. Canaan offers a complete line of intelligent, GMP-compliant systems that simplify operations and improve output. From granulation to tablet compression and film coating, their technology supports you every step of the way. Explore our full collection of Oral Solid Dosage Equipment at Canaan to upgrade your pharmaceutical production line with confidence. [Total Solution Build Your Smart Factory Explore Canaan’s turnkey OSD solutions designed for 21 CFR Part 11 compliance. Explore Solutions → ](https://www.chinacanaan.com/wp-content/uploads/wp-mfa-exports/page/solution.md)